ERIC Number: EJ767914
Record Type: Journal
Publication Date: 2004-Jul
Pages: 6
Abstractor: Author
ISBN: N/A
ISSN: ISSN-1072-0502
EISSN: N/A
The Roles of MAPK Cascades in Synaptic Plasticity and Memory in "Aplysia": Facilitatory Effects and Inhibitory Constraints
Sharma, Shiv K.; Carew, Thomas J.
Learning & Memory, v11 n4 p373-378 Jul 2004
Synaptic plasticity is thought to contribute to memory formation. Serotonin-induced facilitation of sensory-motor (SN-MN) synapses in "Aplysia" is an extensively studied cellular analog of memory for sensitization. Serotonin, a modulatory neurotransmitter, is released in the CNS during sensitization training, and induces three temporally and mechanistically distinct phases of SN-MN synaptic facilitation. The role of protein kinase A and protein kinase C in SN-MN synaptic facilitation is well documented. Recently, it has become clear that mitogen-activated protein kinase (MAPK) cascades also play a critical role in SN-MN plasticity. Here, we summarize the roles of MAPK cascades in synaptic plasticity and memory for sensitization in "Aplysia." (Contains 1 figure.)
Descriptors: Memory, Perceptual Motor Learning, Sensory Experience, Sensory Training, Neurological Organization, Cytology, Molecular Biology, Animals, Short Term Memory, Long Term Memory, Stimuli, Stimulation, Inhibition, Logical Thinking
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Publication Type: Information Analyses; Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A