The scant literature on persistence of African American males in science typically takes a deficits-based approach to encapsulate the myriad reasons this population is so often underrepresented. Scientist Identity, Mentoring, and Campus Climate have, individually, been found to be related to the persistence of African American students. However, the unified impact of these three variables on the persistence of African American students with science interests has not been evaluated, and the relationship between the variables, the students' gender, and markers of academic achievement have not been previously investigated. The current study takes a strengths-based approach to evaluating the relationship between Scientist Identity, Mentoring, and Campus climate with a population of African American students with science interests who were studying at six Minority Serving Institutions and Predominantly White Institutions in the Southern United States. Multiple regression analyses were conducted to determine the impact of Scientist Identity, Mentoring, and Campus Climate on Intention to Persist of African American males. The results indicate that Scientist Identity predicts Intention to Persist, and that gender, academic performance, and institution type moderate the relationship between Scientist Identity and Intention to Persist. These results lend credence to the emerging notion that, for African American men studying science, generating a greater depth and breadth of understanding of the factors that lead to persistence will aid in the development of best practices for supporting persistence among this perpetually underrepresented population. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]