Objective: To assess acceptability of food safety education delivered by interactive multimedia (IMM) in a Supplemental Nutrition Program for Women, Infants and Children Program (WIC) clinic. Methods: Female clients or caregivers (n = 176) completed the food-handling survey; then an IMM food safety education program on a computer kiosk. Satisfaction with program, participant demographics, and change in food-handling behavior were assessed by univariate analyses. Results: Over 90% of the participants enjoyed the kiosk, and most (87.5%) reported using computers a lot. Compared with participants with education beyond high school, participants with less education were more likely to report enjoying the kiosk (98.2% vs 88.1%, P = 0.007), preferred learning with the kiosk (91.7% vs 79.1%, P = 0.02), and would like to learn about other topics using IMM (95.4% vs 86.6%, P = 0.04). Conclusions and Implications: Food safety education delivered by IMM was well accepted by inner-city WIC clinic clients, including those with less education. (Contains 1 table.)