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ERIC Number: EJ929749
Record Type: Journal
Publication Date: 2011-Jul
Pages: 14
Abstractor: As Provided
ISSN: ISSN-1363-755X
Strength of Default Mode Resting-State Connectivity Relates to White Matter Integrity in Children
Gordon, Evan M.; Lee, Philip S.; Maisog, Jose M.; Foss-Feig, Jennifer; Billington, Michael E.; VanMeter, John; Vaidya, Chandan J.
Developmental Science, v14 n4 p738-751 Jul 2011
A default mode network of brain regions is known to demonstrate coordinated activity during the resting state. While the default mode network is well characterized in adults, few investigations have focused upon its development. We scanned 9-13-year-old children with diffusion tensor imaging and resting-state functional magnetic resonance imaging. We identified resting-state networks using Independent Component Analysis and tested whether the functional connectivity between the medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC) depends upon the maturation of the underlying cingulum white matter tract. To determine the generalizability of this relationship, we also tested whether functional connectivity depends on white matter maturity between bilateral lateral prefrontal cortex (lateral PFC) within the executive control network. We found a positive relationship between mPFC-PCC connectivity and fractional anisotropy of the cingulum bundle; this positive relationship was moderated by the age of the subjects such that it was stronger in older children. By contrast, no such structure-function relationship emerged between right and left lateral PFC. However, functional and structural connectivity of this tract related positively with cognitive speed, fluency, and set-switching neuropsychological measures.
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A