ERIC Number: EJ718430
Record Type: Journal
Publication Date: 2005-Sep
Blink Rate in Boys with Fragile X Syndrome: Preliminary Evidence for Altered Dopamine Function
Roberts, J. E.; Symons, F. J.; Johnson, A.-M.; Hatton, D. D.; Boccia, M. L.
Journal of Intellectual Disability Research, v49 n9 p647-656 Sep 2005
Background: Dopamine, a neurotransmitter involved in motor and cognitive functioning, can be non-invasively measured via observation of spontaneous blink rates. Blink rates have been studied in a number of clinical conditions including schizophrenia, autism, Parkinsons, and attention deficit/hyperactivity disorder with results implicating either hyper or hypo dopaminergic states. Methods: This study examined spontaneous blink rate in boys with fragile X syndrome (FXS). Blink rates of boys (4-8 years old) with FXS (n=6) were compared with those of age-matched typically developing boys (n=6) during active and passive tasks. Blink rates (blinks per minute) for each task were compared between the two groups. Then, the relation between blink measures and core FXS-related features [problem behaviours, arousal, fmr 1 protein (FMRP)] were examined within the group of boys with FXS. Results: Blink rate in boys with FXS was significantly higher than typically developing boys during passive tasks. Within the FXS group, there were significant correlations between blink rate and problem behaviours and physiological arousal (i.e. heart activity) but not with FMRP. Conclusions: Observed differences in spontaneous blink rate between boys with and without FXS and the relation between blink rate and physiological and behavioural measures in boys with FXS suggests that further work examining dopamine dysfunction as a factor in the pathophysiology of FXS may be warranted.
Descriptors: Schizophrenia, Males, Hyperactivity, Mental Retardation, Congenital Impairments, Young Children, Behavior Problems, Arousal Patterns, Neurological Impairments
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
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