This study examined associations of loneliness and relationships (e.g., teacher/student relationships, peer support, and family support) with wellbeing among Latina/o middle school students. A hierarchical regression analysis demonstrated that age and loneliness predicted wellbeing; older students and students with high levels of loneliness reported higher wellbeing. The interaction effect between loneliness and peer support suggested that peer support was related with wellbeing only among students high in loneliness. Similarly, the interaction effect between loneliness and family support suggested that family support was associated with wellbeing only among students high in loneliness. Implications for addressing cultural determinants of wellbeing are provided.