ERIC Number: EJ1162912
Record Type: Journal
Publication Date: 2017-Dec
Abstractor: As Provided
Effects of Regulatory BC1 RNA Deletion on Synaptic Plasticity, Learning, and Memory
Chung, Ain; Dahan, Nessy; Alarcon, Juan Marcos; Fenton, André A.
Learning & Memory, v24 n12 p646-649 Dec 2017
Nonprotein coding dendritic BC1 RNA regulates translation of mRNAs in neurons. We examined two lines of BC1 knockout mice and report that loss of BC1 RNA exaggerates group I mGluR-stimulated LTD of the Schaffer collateral synapse, with one of the lines showing a much more enhanced DHPG-induced LTD than the other. When the animals were given the hippocampus-synaptic plasticity-dependent active place avoidance task, learning and memory were impaired in the BC1-KO line with the more severely altered DHPG-induced LTD. These findings indicate a role for BC1 RNA control of mGluR-dependent synaptic function in hippocampus and associated cognitive ability.
Descriptors: Memory, Brain Hemisphere Functions, Biochemistry, Animals, Cognitive Ability, Learning Processes, Task Analysis, Role, Genetics
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Sponsor: National Institutes of Health (DHHS)
Authoring Institution: N/A
Grant or Contract Numbers: NS081625; NS091830; MH099128