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Iacoangeli, Anna; Dosunmu, Aderemi; Eom, Taesun; Stefanov, Dimitre G.; Tiedge, Henri – Learning & Memory, 2017
Dendritic regulatory BC1 RNA is a non-protein-coding (npc) RNA that operates in the translational control of gene expression. The absence of BC1 RNA in BC1 knockout (KO) animals causes translational dysregulation that entails neuronal phenotypic alterations including prolonged epileptiform discharges, audiogenic seizure activity in vivo, and…
Descriptors: Genetics, Animals, Brain Hemisphere Functions, Brain
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Chung, Ain; Dahan, Nessy; Alarcon, Juan Marcos; Fenton, André A. – Learning & Memory, 2017
Nonprotein coding dendritic BC1 RNA regulates translation of mRNAs in neurons. We examined two lines of BC1 knockout mice and report that loss of BC1 RNA exaggerates group I mGluR-stimulated LTD of the Schaffer collateral synapse, with one of the lines showing a much more enhanced DHPG-induced LTD than the other. When the animals were given the…
Descriptors: Memory, Brain Hemisphere Functions, Biochemistry, Animals
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Mott, John E. – American Biology Teacher, 1984
Examines heterologous expression in Escherichia coli and the role of regulatory sequences which control gene expression at transcription resulting in abundant production of messenger RNA and regulatory sequences in mRNA which promote efficient translation. Also examines the role of E. coli cells in stabilizing mRNA and protein that is…
Descriptors: Biochemistry, College Science, DNA, Genetic Engineering
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Sengupta, Sibani – American Biology Teacher, 2013
RNA interference (abbreviated RNAi) is a relatively new discovery in the field of mechanisms that serve to regulate gene expression (a.k.a. protein synthesis). Gene expression can be regulated at the transcriptional level (mRNA production, processing, or stability) and at the translational level (protein synthesis). RNAi acts in a gene-specific…
Descriptors: Genetics, Science Instruction, High School Students, Secondary School Science
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Ellington, Roni; Wachira, James; Nkwanta, Asamoah – CBE - Life Sciences Education, 2010
The focus of this Research Experience for Undergraduates (REU) project was on RNA secondary structure prediction by using a lattice walk approach. The lattice walk approach is a combinatorial and computational biology method used to enumerate possible secondary structures and predict RNA secondary structure from RNA sequences. The method uses…
Descriptors: Genetics, Prediction, Microbiology, Epilepsy
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Szeberenyi, Jozsef – Biochemistry and Molecular Biology Education, 2010
This paper presents a problem-solving test that deals with the regulation of the "trp" operon of "Escherichia coli." Two mutants of this operon are described: in mutant A, the operator region of the operon carries a point mutation so that it is unable to carry out its function; mutant B expresses a "trp" repressor protein unable to bind…
Descriptors: Problem Solving, Genetics, Microbiology, Science Tests
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Kelley, Ann E.; Hernandez, Pepe J.; Schiltz, Craig A. – Learning & Memory, 2006
Adaptive motor actions require prior knowledge of instrumental contingencies. With practice, these actions can become highly automatic in nature. However, the molecular and anatomical substrates mediating these related forms of learning are not understood. In the present study, we used in situ hybridization to measure the mRNA levels of two…
Descriptors: Habit Formation, Prior Learning, Training, Genetics
Dassanayake, Maheshi – ProQuest LLC, 2009
Mangroves represent phylogenetically diverse taxa in tropical coastal terrestrial habitats. They are extremophiles, evolutionarily adapted to tolerate flooding, anoxia, high temperatures, wind, and high and extremely variable salt conditions in typically resource-poor environments. The genetic basis for these adaptations is, however, virtually…
Descriptors: Forestry, Ecology, Genetics, Physiology