ERIC Number: EJ951497
Record Type: Journal
Publication Date: 2011-Dec
Abstractor: As Provided
Biotechnology in the Treatment of Sensorineural Hearing Loss: Foundations and Future of Hair Cell Regeneration
Parker, Mark A.
Journal of Speech, Language, and Hearing Research, v54 n6 p1709-1731 Dec 2011
Purpose: To provide an overview of the methodologies involved in the field of hair cell regeneration. First, the author provides a tutorial on the biotechnological foundations of this field to assist the reader in the comprehension and interpretation of the research involved in hair cell regeneration. Next, the author presents a review of stem cell and gene therapy and provides a critical appraisal of their application to hair cell regeneration. The methodologies used in these approaches are highlighted. Method: The author conducted a narrative review of the fields of cellular, molecular, and developmental biology, tissue engineering, and stem cell and gene therapy using the PubMed database. Results: The use of biotechnological approaches to the treatment of hearing loss--approaches such as stem cell and gene therapy--has led to new methods of regenerating cochlear hair cells in mammals. Conclusions: Incredible strides have been made in assembling important pieces of the puzzle that comprise hair cell regeneration. However, mammalian hair cell regeneration using stem cell and gene therapy are years--if not decades--away from being clinically feasible. If the goals of the biological approaches are met, these therapies may represent future treatments for hearing loss.
Descriptors: Hearing Impairments, Biotechnology, Therapy, Genetics, Cytology, Molecular Biology, Developmental Stages, Human Body
American Speech-Language-Hearing Association (ASHA). 10801 Rockville Pike, Rockville, MD 20852. Tel: 800-638-8255; Fax: 301-571-0457; e-mail: email@example.com; Web site: http://jslhr.asha.org
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A