Women with breast cancer frequently report psychological distress throughout the treatment process. Patients have several empirically supported options for group psychotherapy while undergoing breast cancer treatment. However, few interventions have been developed that incorporate spirituality into psychotherapy, despite indications that patients desire such treatment. Psycho-Spiritual Integrative Therapy (PSIT) incorporates principles of third-wave Cognitive Behavioral Therapy, mindfulness, and passage meditation to provide women with breast cancer with an intervention that addresses both psychological and spiritual needs. Preliminary research suggests that PSIT is associated with improved quality of life, mood, and physical, psychological, and spiritual well-being in women with breast cancer. (Contains 1 table.)