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Pine, Daniel S.; Ernst, Monique; Leibenluft, Ellen – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: To place imaging-genetics research in the context of child psychiatry. Method: A conceptual overview is provided, followed by discussion of specific research examples. Results: Imaging-genetics research is described linking brain function to two specific genes, for the serotonin-reuptake-transporter protein and a monoamine oxidase…
Descriptors: Psychiatry, Genetics, Brain, Drug Therapy
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McClure, Erin B.; Treland, Julia E.; Snow, Joseph; Dickstein, Daniel P.; Towbin, Kenneth E.; Charney, Dennis S.; Pine, Daniel S.; Leibenluft, Ellen – Journal of the American Academy of Child and Adolescent Psychiatry, 2005
Objective: To test the hypothesis that patients with pediatric bipolar disorder (PBPD) would demonstrate impairment relative to diagnosis-free controls of comparable age, gender, and IQ on measures of memory functioning. Method: The authors administered a battery of verbal and visuospatial memory tests to 35 outpatients with PBPD and 20 healthy…
Descriptors: Psychological Patterns, Verbal Learning, Psychiatry, Patients
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Deveney, Christen M.; Brotman, Melissa A.; Decker, Ann Marie; Pine, Daniel S.; Leibenluft, Ellen – Journal of Child Psychology and Psychiatry, 2012
Background: Accurate identification of nonverbal emotional cues is essential to successful social interactions, yet most research is limited to emotional face expression labeling. Little research focuses on the processing of emotional prosody, or tone of verbal speech, in clinical populations. Methods: Using the Diagnostic Analysis of Nonverbal…
Descriptors: Sentences, Cues, Symptoms (Individual Disorders), Patients
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Wakschlag, Lauren S.; Choi, Seung W.; Carter, Alice S.; Hullsiek, Heide; Burns, James; McCarthy, Kimberly; Leibenluft, Ellen; Briggs-Gowan, Margaret J. – Journal of Child Psychology and Psychiatry, 2012
Background: Temper modulation problems are both a hallmark of early childhood and a common mental health concern. Thus, characterizing specific behavioral manifestations of temper loss along a dimension from normative misbehaviors to clinically significant problems is an important step toward identifying clinical thresholds. Methods:…
Descriptors: Psychopathology, Item Response Theory, Measures (Individuals), Mental Health
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Adleman, Nancy E.; Fromm, Stephen J.; Razdan, Varun; Kayser, Reilly; Dickstein, Daniel P.; Brotman, Melissa A.; Pine, Daniel S.; Leibenluft, Ellen – Journal of Child Psychology and Psychiatry, 2012
Background: There is debate as to whether chronic irritability (operationalized as severe mood dysregulation, SMD) is a developmental form of bipolar disorder (BD). Although structural brain abnormalities in BD have been demonstrated, no study compares neuroanatomy among SMD, BD, and healthy volunteers (HV) either cross-sectionally or over time.…
Descriptors: Psychological Patterns, Brain Hemisphere Functions, Mental Disorders, Attention Deficit Disorders
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Britton, Jennifer C.; Bar-Haim, Yair; Carver, Frederick W.; Holroyd, Tom; Norcross, Maxine A.; Detloff, Allison; Leibenluft, Ellen; Ernst, Monique; Pine, Daniel S. – Journal of Child Psychology and Psychiatry, 2012
Background: Attention biases toward threat are often detected in individuals with anxiety disorders. Threat biases can be measured experimentally through dot-probe paradigms, in which individuals detect a probe following a stimulus pair including a threat. On these tasks, individuals with anxiety tend to detect probes that occur in a location…
Descriptors: Anxiety Disorders, Cues, Attention Control, Anxiety
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Stringaris, Argyris; Goodman, Robert; Ferdinando, Sumudu; Razdan, Varun; Muhrer, Eli; Leibenluft, Ellen; Brotman, Melissa A. – Journal of Child Psychology and Psychiatry, 2012
Background: Irritable mood has recently become a matter of intense scientific interest. Here, we present data from two samples, one from the United States and the other from the United Kingdom, demonstrating the clinical and research utility of the parent- and self-report forms of the Affective Reactivity Index (ARI), a concise dimensional measure…
Descriptors: Mental Health, Parent Attitudes, Depression (Psychology), Emotional Problems
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Towbin, Kenneth; Axelson, David; Leibenluft, Ellen; Birmaher, Boris – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: Bipolar disorder--not otherwise specified (BP-NOS) and severe mood dysregulation (SMD) are severe mood disorders that were defined to address questions about the diagnosis of bipolar disorder (BD) in youth. SMD and BP-NOS are distinct phenotypes that differ in clinical presentation and longitudinal course. The purpose of this review is…
Descriptors: Psychological Patterns, Mental Disorders, Genetics, Symptoms (Individual Disorders)
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Olsavsky, Aviva K.; Brotman, Melissa A.; Rutenberg, Julia G.; Muhrer, Eli J.; Deveney, Christen M.; Fromm, Stephen J.; Towbin, Kenneth; Pine, Daniel S.; Leibenluft, Ellen – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: Youth at familial risk for bipolar disorder (BD) show deficits in face emotion processing, but the neural correlates of these deficits have not been examined. This preliminary study tests the hypothesis that, relative to healthy comparison (HC) subjects, both BD subjects and youth at risk for BD (i.e., those with a first-degree BD…
Descriptors: Attention Deficit Hyperactivity Disorder, Anxiety Disorders, At Risk Students, Longitudinal Studies
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Stringaris, Argyris; Santosh, Paramala; Leibenluft, Ellen; Goodman, Robert – Journal of Child Psychology and Psychiatry, 2010
Background: Little is known about short-duration episodes of mania-like symptoms in youth. Here we determine the prevalence, morbid associations, and contribution to social impairment of a phenotype characterised by episodes during which symptom and impairment criteria for mania are met, but DSM-IV duration criteria are not (bipolar not otherwise…
Descriptors: Incidence, Autism, Criteria, Psychopathology
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Adleman, Nancy E.; Kayser, Reilly; Dickstein, Daniel; Blair, R. James R.; Pine, Daniel; Leibenluft, Ellen – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: Outcome and family history data differentiate children with severe mood dysregulation (SMD), a syndrome characterized by chronic irritability, from children with "classic" episodic bipolar disorder (BD). Nevertheless, the presence of cognitive inflexibility in SMD and BD highlights the need to delineate neurophysiologic similarities and…
Descriptors: Attention Deficit Hyperactivity Disorder, Psychological Patterns, Neurological Organization, Severe Disabilities
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Baroni, Argelinda; Lunsford, Jessica R.; Luckenbaugh, David A.; Towbin, Kenneth E.; Leibenluft, Ellen – Journal of Child Psychology and Psychiatry, 2009
Background: An increasing number of youth are being diagnosed with, and treated for, bipolar disorder (BD). Controversy exists about whether youth with non-episodic irritability and symptoms of attention deficit hyperactivity disorder (ADHD) should be considered to have a developmental presentation of mania. Method: A selective review of the…
Descriptors: Attention Deficit Hyperactivity Disorder, Psychological Patterns, Evaluation Methods, Mental Disorders
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Britton, Jennifer C.; Rauch, Scott L.; Rosso, Isabelle M.; Killgore, William D. S.; Price, Lauren M.; Ragan, Jennifer; Chosak, Anne; Hezel, Dianne M.; Pine, Daniel S.; Leibenluft, Ellen; Pauls, David L.; Jenike, Michael A.; Stewart, S. Evelyn – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Deficits in cognitive flexibility and response inhibition have been linked to perturbations in cortico-striatal-thalamic circuitry in adult obsessive-compulsive disorder (OCD). Although similar cognitive deficits have been identified in pediatric OCD, few neuroimaging studies have been conducted to examine its neural correlates in the…
Descriptors: Anxiety Disorders, Reaction Time, Shift Studies, Correlation
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Stringaris, Argyris; Baroni, Argelinda; Haimm, Caroline; Brotman, Melissa; Lowe, Catherine H.; Myers, Frances; Rustgi, Eileen; Wheeler, Wanda; Kayser, Reilly; Towbin, Kenneth; Leibenluft, Ellen – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: An important question in pediatric bipolar research is whether marked nonepisodic irritability is a manifestation of bipolar disorder in youth. This study tests the hypothesis that youth with severe mood dysregulation (SMD), a category created for the purpose of studying children presenting with severe nonepisodic irritability, will be…
Descriptors: Mental Disorders, Depression (Psychology), Psychological Patterns, Patients
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Liu, Xinmin; Akula, Nirmala; Skup, Martha; Brotman, Melissa A.; Leibenluft, Ellen; McMahon, Francis J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Functional magnetic resonance imaging is commonly used to characterize brain activity underlying a variety of psychiatric disorders. A previous functional magnetic resonance imaging study found that amygdala activation during a face-processing task differed between pediatric patients with bipolar disorder (BD) and healthy controls. We…
Descriptors: Quality Control, Adolescents, Patients, Genetics
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