Background: The study considers how severity of disability, perceived stress, and perceived social support impact on the well-being of a group of mothers caring for school-aged children with cerebral palsy. Method: Forty-three mothers attending clinics at the Royal Children's Hospital in Melbourne, Australia were interviewed and completed the "Profile of Adaptation to Life Scale," the "Satisfaction with Life Scale," the "Perceived Stress Scale," and the "Multidimensional Scale of Perceived Social Support." Results: The results confirmed that severity of disability was not significantly related to maternal well-being, but that perceived stress and perceived social support significantly predicted well-being, both independently and together. Conclusion: Social support was found to have a slight to moderate role in mediating the impact of stress on these mothers.