ERIC Number: EJ1120614
Record Type: Journal
Publication Date: 2016-Dec
Abstractor: As Provided
Rats Can Acquire Conditional Fear of Faint Light Leaking through the Acrylic Resin Used to Mount Fiber Optic Cannulas
Eckmier, Adam; de Marcillac, Willy Daney; Maître, Agnès; Jay, Thérèse M.; Sanders, Matthew J.; Godsil, Bill P.
Learning & Memory, v23 n12 p684-688 Dec 2016
Rodents are exquisitely sensitive to light and optogenetic behavioral experiments routinely introduce light-delivery materials into experimental situations, which raises the possibility that light could leak and influence behavioral performance. We examined whether rats respond to a faint diffusion of light, termed caplight, which emanated through the translucent dental acrylic resin used to affix deep-brain optical cannulas in place. Although rats did not display significant changes in locomotion or rearing to caplight in a darkened open field, they did acquire conditional fear via caplight-footshock pairings. These findings highlight the potential confounding influence of extraneous light emanating from light-delivery materials during optogenetic analyses.
Descriptors: Animals, Light, Animal Behavior, Fear, Influences, Visual Stimuli, Conditioning, Optics
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A