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ERIC Number: EJ830391
Record Type: Journal
Publication Date: 2009
Pages: 6
Abstractor: As Provided
ISSN: ISSN-1750-9467
A Preliminary Study of Gene Polymorphisms Involved in the Neurotransmitters Metabolism of a Homogeneous Spanish Autistic Group
Calahorro, Fernando; Alejandre, Encarna; Anaya, Nuria; Guijarro, Teresa; Sanz, Yolanza; Romero, Auxiliadora; Tienda, Pilar; Burgos, Rafael; Gay, Eudoxia; Sanchez, Vicente; Ruiz-Rubio, Manuel
Research in Autism Spectrum Disorders, v3 n2 p438-443 Apr-Jun 2009
Twin studies have shown a strong genetic component for autism. Neurotransmitters, such as serotonin and catecholamines, have been suggested to play a role in the disease since they have an essential function in synaptogenesis and brain development. In this preliminary study, polymorphism of genes implicated in the serotonergic and dopaminergic pathways have been examined in a Spanish population of children diagnosed with autism. Significant association with the disorder was found for the short allele in the promoter of the gene encoding the serotonin transporter (SLC6A4); in addition, a preferential maternal transmission of this allele to affected offspring was observed. (Contains 4 tables.)
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Location: Spain