ERIC Number: EJ916776
Record Type: Journal
Publication Date: 2010-Sep
Abstractor: As Provided
Side Effects of Minocycline Treatment in Patients with Fragile X Syndrome and Exploration of Outcome Measures
Utari, Agustini; Chonchaiya, Weerasak; Rivera, Susan M.; Schneider, Andrea; Hagerman, Randi J.; Faradz, Sultana M. H.; Ethell, Iryna M.; Nguyen, Danh V.
American Journal on Intellectual and Developmental Disabilities, v115 n5 p433-443 Sep 2010
Minocycline can rescue the dendritic spine and synaptic structural abnormalities in the fragile X knock-out mouse. This is a review and preliminary survey to document side effects and potential outcome measures for minocycline use in the treatment of individuals with fragile X syndrome. We surveyed 50 patients with fragile X syndrome who received minocycline for at least 2 weeks and found that the most common reported side effect is gastrointestinal difficulty, including loss of appetite. The families reported an improvement in language and behavioral areas. Outcome measures in the design of future randomized clinical trials should include both behavioral and language measures. As with any other treatments, we emphasize that randomized clinical trials are needed to determine the efficacy of minocycline in fragile X syndrome.
Descriptors: Behavior Disorders, Patients, Drug Therapy, Genetic Disorders, Symptoms (Individual Disorders), Human Body, Surveys, Outcomes of Treatment, Behavior Change, Language Skills, Eating Disorders
American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://aaidd.allenpress.com
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A