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ERIC Number: EJ979747
Record Type: Journal
Publication Date: 2012-Jan
Pages: 7
Abstractor: As Provided
ISSN: ISSN-0021-9584
Integrated Teaching of Structure-Based Drug Design and Biopharmaceutics: A Computer-Based Approach
Sutch, Brian T.; Romero, Rebecca M.; Neamati, Nouri; Haworth, Ian S.
Journal of Chemical Education, v89 n1 p45-51 Jan 2012
Rational drug design requires expertise in structural biology, medicinal chemistry, physiology, and related fields. In teaching structure-based drug design, it is important to develop an understanding of the need for early recognition of molecules with "drug-like" properties as a key component. That is, it is not merely sufficient to teach students how to design an effective inhibitor for a particular protein; instead, it is important to convey the need for simultaneous consideration of biopharmaceutical properties that will optimize the chances of the inhibitor becoming a drug. These are advanced concepts, but they can be addressed through computer-based methods. Here, an educational approach using a case study is described in which students "design" a potential drug through use of software, most of which is Web-based and freely available. (Contains 2 tables and 3 figures.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail:; Web site:
Publication Type: Journal Articles; Reports - Descriptive
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A