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Showing 16 to 30 of 67 results Save | Export
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Costa, Nancy E.; Pelotte, Andrea L.; Simard, Joseph M.; Syvinski, Christopher A.; Deveau, Amy M. – Journal of Chemical Education, 2012
Suzuki couplings are powerful chemical reactions commonly employed in academic and industrial research settings to generate functionalized biaryls. We have developed and implemented a discovery-based, microscale experiment for the undergraduate organic chemistry laboratory that explores green Suzuki coupling using water as the primary solvent.…
Descriptors: Organic Chemistry, Problem Solving, Science Instruction, College Science
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Hakim, Aliefman; Liliasari; Kadarohman, Asep; Syah, Yana Maolana – Journal of Chemical Education, 2016
This paper discusses laboratory activities that can improve the meaningfulness of natural product chemistry course. These laboratory activities can be useful for students from many different disciplines including chemistry, pharmacy, and medicine. Students at the third-year undergraduate level of chemistry education undertake the project to…
Descriptors: Science Laboratories, Undergraduate Students, College Science, Organic Chemistry
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Hamilton, Todd M.; Wiseman, Frank L., Jr. – Journal of Chemical Education, 2009
Fluorescence spectroscopy is used to determine the quantity of dextromethorphan hydrobromide (DM) in over-the-counter (OTC) cough drops and syrups. This experiment is appropriate for an undergraduate medicinal chemistry laboratory course when studying OTC medicines and active ingredients. Students prepare the cough drops and syrups for analysis,…
Descriptors: Chemistry, Medicine, Spectroscopy, College Science
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Sutch, Brian T.; Romero, Rebecca M.; Neamati, Nouri; Haworth, Ian S. – Journal of Chemical Education, 2012
Rational drug design requires expertise in structural biology, medicinal chemistry, physiology, and related fields. In teaching structure-based drug design, it is important to develop an understanding of the need for early recognition of molecules with "drug-like" properties as a key component. That is, it is not merely sufficient to teach…
Descriptors: Biology, Chemistry, Physiology, Science Instruction
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Geldenhuys, Werner J.; Hayes, Michael; Van der Schyf, Cornelis J.; Allen, David D.; Malan, Sarel F. – Journal of Chemical Education, 2007
A simple, novel and generally applicable method to demonstrate structure-activity associations of a group of biologically interesting compounds in relation to receptor binding is described. This method is useful for undergraduates and graduate students in medicinal chemistry and computer modeling programs.
Descriptors: Chemistry, College Science, Undergraduate Study, Graduate Study
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Kadnikova, Ekaterina N. – Journal of Chemical Education, 2013
To accentuate the importance of organic chemistry in development of contemporary pharmaceuticals, a three-week unit entitled "Molecules-in-Medicine" was included in the curriculum of a comprehensive one-semester four-credit organic chemistry course. After a lecture on medicinal chemistry concepts and pharmaceutical practices, students…
Descriptors: Organic Chemistry, Peer Evaluation, Curriculum Enrichment, Pharmaceutical Education
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Soares, Pedro; Fernandes, Carlos; Chavarria, Daniel; Borges, Fernanda – Journal of Chemical Education, 2015
In recent years, the use of boron-containing reagents in palladium-assisted C-C coupling reactions (the Suzuki reaction) has gained prominence due to the vast array of reagents commercially available. Consequently, the generation of carbon-carbon bonds, namely of functionalized biphenyl systems, is at present considered the backbone of organic…
Descriptors: Science Instruction, Science Laboratories, Laboratory Equipment, Teaching Methods
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Fletcher, James T.; Boriraj, Grit – Journal of Chemical Education, 2010
A second-year organic chemistry laboratory experiment to introduce students to general concepts of medicinal chemistry is described. Within a single three-hour time window, students experience the synthesis of a biologically active small molecule and the assaying of its biological toxicity. Benzodiazepine rings are commonly found in antidepressant…
Descriptors: Organic Chemistry, Laboratory Experiments, College Science, Science Instruction
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Manallack, David T.; Chalmers, David K.; Yuriev, Elizabeth – Journal of Chemical Education, 2010
The topics of molecular modeling and drug design are studied in a medicinal chemistry course. The recently reported structures of several G protein-coupled receptors (GPCR) with bound ligands have been used to develop a simple computer-based experiment employing molecular-modeling software. Knowledge of the specific interactions between a ligand…
Descriptors: Undergraduate Study, Biochemistry, College Science, Science Instruction
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Stowe, Ryan; Elvey, Jacob – Science Teacher, 2016
Chemistry in high school is often presented as a jumbled mass of topics drawn from inorganic, analytical, and physical sub-disciplines. With no central theme to build on, students may have trouble grasping the chemical sciences as a coherent field. In this article, Stowe and Elvey describe an activity that integrates different facets of chemistry…
Descriptors: Computer Assisted Design, Chemistry, Biochemistry, Molecular Biology
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Viegas, Aldino; Manso, Joao; Nobrega, Franklin L.; Cabrita, Eurico J. – Journal of Chemical Education, 2011
Saturation transfer difference (STD) NMR has emerged as one of the most popular ligand-based NMR techniques for the study of protein-ligand interactions. The success of this technique is a consequence of its robustness and the fact that it is focused on the signals of the ligand, without any need of processing NMR information about the receptor…
Descriptors: Chemistry, Biochemistry, College Science, Science Instruction
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Rodrigues, Ricardo P.; Andrade, Saulo F.; Mantoani, Susimaire P.; Eifler-Lima, Vera L.; Silva, Vinicius B.; Kawano, Daniel F. – Journal of Chemical Education, 2015
Advances in, and dissemination of, computer technologies in the field of drug research now enable the use of molecular modeling tools to teach important concepts of drug design to chemistry and pharmacy students. A series of computer laboratories is described to introduce undergraduate students to commonly adopted "in silico" drug design…
Descriptors: Undergraduate Study, Chemistry, College Science, Pharmacology
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Streu, Craig N.; Reif, Randall D.; Neiles, Kelly Y.; Schech, Amanda J.; Mertz, Pamela S. – Journal of Chemical Education, 2016
Integrative, research-based experiences have shown tremendous potential as effective pedagogical approaches. Pharmaceutical development is an exciting field that draws heavily on organic chemistry and biochemistry techniques. A capstone drug synthesis/analysis laboratory is described where biochemistry students synthesize azo-stilbenoid compounds…
Descriptors: Science Instruction, College Science, Undergraduate Study, Biochemistry
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Wolyniak, Michael J.; Alvarez, Consuelo J.; Chandrasekaran, Vidya; Grana, Theresa M.; Holgado, Andrea; Jones, Christopher J.; Morris, Robert W.; Pereira, Anil L.; Stamm, Joyce; Washington, Talitha M.; Yang, Yixin – CBE - Life Sciences Education, 2010
Synthetic biology is the application of engineering and mathematical principles to develop novel biological devices and circuits. What separates synthetic biology from traditional molecular biology is the development of standardized interchangeable DNA "parts," just as advances in engineering in the nineteenth century brought about standardized…
Descriptors: Genetics, Biology, Workshops, Consortia
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Santaniello, Brandi S.; Price, Matthew J.; Murray, James K., Jr. – Journal of Chemical Education, 2017
A straightforward synthesis of 2-phenylimidazo[1,2-a]pyridine is described. The reaction is designed to demonstrate to students the preparation of a bridged N-heterocycle, in which the heteroatom occupies a bridgehead position. The product is obtained in moderate to high yield and is highly crystalline. The compound can be purified either by…
Descriptors: Undergraduate Students, Organic Chemistry, Medicine, Science Laboratories
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