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ERIC Number: EJ979778
Record Type: Journal
Publication Date: 2012-Jan
Pages: 3
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
A Safer and Convenient Synthesis of Sulfathiazole for Undergraduate Organic and Medicinal Chemistry Classes
Boyle, Jeff; Otty, Sandra; Sarojini, Vijayalekshmi
Journal of Chemical Education, v89 n1 p141-143 Jan 2012
A safer method for the synthesis of the sulfonamide drug sulfathiazole, for undergraduate classes, is described. This method improves upon procedures currently followed in several undergraduate teaching laboratories for the synthesis of sulfathiazole. Key features of this procedure include the total exclusion of pyridine, which has potential health hazards, from the first step of the synthesis and a simplified procedure for converting the intermediate p-acetamidobenzenesulfonamide to the final product by acid hydrolysis. Characterization of the synthetic sulfathiazole obtained by the modified route was achieved using MS, NMR, and antibacterial activity testing of the synthetic product against "Escherichia coli" DH5[alpha]. (Contains 2 tables and 2 schemes.)
Division of Chemical Education, Inc and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A