In this article, the author discusses ways in which teachers can implement brain-based research in teaching English language learners (ELLs). Teachers of ELLs can draw on recently developed brain-based research applied to other learners, in addition to their considerations of multicultural strategies, learning styles, and diverse needs. Equipped with an array of diverse teaching approaches, ELL teachers can tap into the best of brain-compatible learning and neurodevelopmental applications, providing innovative ways to reach students.