Intracranial surgery means any surgery performed inside the skull to treat problems in the brain and surrounding structures. Aim: Evaluate the impact of nursing educational program on reducing or preventing postoperative complications for patients after intracranial surgery. Subjects and methods: Sixty adult patients had intracranial surgery (burr hole, craniotomy and craniectomy) were included in this study. Their age ranged from 18-65 years old, fully conscious after operation. Patients divided into two groups; control group (30 patients who received routine care) and study group (30 patients who received nursing educational program). Three tools were used for data collection; tool I patient assessment sheet, tool II nursing educational program after intracranial surgery and tool III patient evaluation sheet. Results: A good improvement in total knowledge scores of study group patients after application of nursing educational program. Significant reduction and/or prevention of systemic and neurosurgical postoperative complications for study group patients after application of nursing educational program. Conclusion: Improving patients' knowledge in study group had a favorable effect in reducing or preventing systemic and neurosurgical postoperative complications than in control group. Recommendation: Establishment of health care educational center in neurosurgery department to educate patients about their conditions.