Instructional strategies make a difference in whether students are engaged in learning and are profiting from their time in class. High schools, technology centers and middle grades schools are encouraging teachers to adopt new teaching techniques and are providing opportunities for teachers to work together to improve their instructional skills and approaches to make learning relevant for all students. This newsletter describes numerous ways that schools can get students to find more meaning in their studies and improve their academic and technical achievement and outlook for the future. [This newsletter of "best practices" in implementing the "High Schools That Work" ("HSTW"), "Making Middle Grades Work" ("MMGW") and "Technology Centers That Work" ("TCTW") school improvement models is based on presentations at the 24th Annual "HSTW" Staff Development Conference in Louisville, Kentucky, in July 2010.]