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Showing 1 to 15 of 237 results Save | Export
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Vecsey, Christopher G.; Park, Alan J.; Khatib, Nora; Abel, Ted – Learning & Memory, 2015
Sleep deprivation (SD) following hippocampus-dependent learning in young mice impairs memory when tested the following day. Here, we examined the effects of SD on remote memory in both young and aged mice. In young mice, we found that memory is still impaired 1 mo after training. SD also impaired memory in aged mice 1 d after training, but, by a…
Descriptors: Sleep, Memory, Neurological Impairments, Animals
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Shu, Guanhua; Kramár, Enikö A.; López, Alberto J.; Huynh, Grace; Wood, Marcelo A.; Kwapis, Janine L. – Learning & Memory, 2018
Multiple epigenetic mechanisms, including histone acetylation and nucleosome remodeling, are known to be involved in long-term memory formation. Enhancing histone acetylation by deleting histone deacetylases, like HDAC3, typically enhances long-term memory formation. In contrast, disrupting nucleosome remodeling by blocking the neuron-specific…
Descriptors: Long Term Memory, Genetics, Molecular Structure, Neurological Impairments
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Jiang, Alice; Tran, Tammy T.; Madison, Farrah N.; Bakker, Arnold – Learning & Memory, 2019
Stress is a potent modulator of brain function and particularly mnemonic processes. While chronic stress is associated with long-term deficits in memory, the effects of acute stress on mnemonic functions are less clear as previous reports have been inconsistent. Some studies suggest that cortisol, a stress hormone that modulates biological changes…
Descriptors: Stress Variables, Mnemonics, Memory, Control Groups
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Bisby, James A.; Burgess, Neil – Learning & Memory, 2014
The formation of associations between items and their context has been proposed to rely on mechanisms distinct from those supporting memory for a single item. Although emotional experiences can profoundly affect memory, our understanding of how it interacts with different aspects of memory remains unclear. We performed three experiments to examine…
Descriptors: Memory, Animals, Emotional Response, Affective Behavior
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Wardlaw, Sarah M.; Phan, Trongha X.; Saraf, Amit; Chen, Xuanmao; Storm, Daniel R. – Learning & Memory, 2014
Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system. We used a genetic approach to evaluate the role of the molecular clock in memory. Bmal1[superscript -/-] mice, which are arrhythmic…
Descriptors: Genetics, Memory, Sleep, Animals
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Lefer, Damien; Perisse, Emmanuel; Hourcade, Benoit; Sandoz, JeanChristophe; Devaud, Jean-Marc – Learning & Memory, 2013
Storage of information into long-term memory (LTM) usually requires at least two waves of transcription in many species. However, there is no clear evidence of this phenomenon in insects, which are influential models for memory studies. We measured retention in honeybees after injecting a transcription inhibitor at different times before and after…
Descriptors: Long Term Memory, Entomology, Retention (Psychology), Conditioning
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Einarsson, Einar O.; Nader, Karim – Learning & Memory, 2012
It has been suggested that memories become more stable and less susceptible to the disruption of reconsolidation over weeks after learning. Here, we test this by targeting the anterior cingulate cortex (ACC) and test its involvement in the formation, consolidation, and reconsolidation of recent and remote contextual fear memory. We found that…
Descriptors: Memory, Fear, Brain Hemisphere Functions, Biochemistry
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Yu, Dinghui; Tan, Ying; Chakraborty, Molee; Tomchik, Seth; Davis, Ronald L. – Learning & Memory, 2018
The evolutionarily conserved Elongator Complex associates with RNA polymerase II for transcriptional elongation. Elp3 is the catalytic subunit, contains histone acetyltransferase activity, and is associated with neurodegeneration in humans. Elp1 is a scaffolding subunit and when mutated causes familial dysautonomia. Here, we show that…
Descriptors: Olfactory Perception, Animals, Genetics, Memory
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Prince, Toni-Moi; Abel, Ted – Learning & Memory, 2013
Hippocampal cellular and molecular processes critical for memory consolidation are affected by the amount and quality of sleep attained. Questions remain with regard to how sleep enhances memory, what parameters of sleep after learning are optimal for memory consolidation, and what underlying hippocampal molecular players are targeted by sleep…
Descriptors: Sleep, Brain Hemisphere Functions, Memory, Cognitive Processes
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Mulligan, Neil W.; Smith, S. Adam; Spataro, Pietro – Journal of Experimental Psychology: Learning, Memory, and Cognition, 2016
Stimuli co-occurring with targets in a detection task are better remembered than stimuli co-occurring with distractors--the attentional boost effect (ABE). The ABE is of interest because it is an exception to the usual finding that divided attention during encoding impairs memory. The effect has been demonstrated in tests of item memory but it is…
Descriptors: Memory, Attention, Recognition (Psychology), Priming
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Jonker, Tanya R.; MacLeod, Colin M. – Journal of Experimental Psychology: Learning, Memory, and Cognition, 2015
McDaniel and Bugg (2008) proposed that relatively uncommon stimuli and encoding tasks encourage elaborative encoding of individual items (item-specific processing), whereas relatively typical or common encoding tasks encourage encoding of associations among list items (relational processing). It is this relational processing that is thought to…
Descriptors: Memory, Cognitive Processes, Semantics, Interference (Learning)
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Peterson, Daniel J.; Mulligan, Neil W. – Journal of Experimental Psychology: Learning, Memory, and Cognition, 2013
Across 3 experiments, we investigated the factors that dictate when taking a test improves subsequent memory performance (the "testing effect"). In Experiment 1, participants retrieving a set of targets during a retrieval practice phase ultimately recalled fewer of those targets compared with a group of participants who studied the…
Descriptors: Memory, Experimental Psychology, Tests, Recall (Psychology)
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Lotfipour, Shahrdad; Mojica, Celina; Nakauchi, Sakura; Lipovsek, Marcela; Silverstein, Sarah; Cushman, Jesse; Tirtorahardjo, James; Poulos, Andrew; Elgoyhen, Ana Belén; Sumikawa, Katumi; Fanselow, Michael S.; Boulter, Jim – Learning & Memory, 2017
The absence of a2* nicotinic acetylcholine receptors (nAChRs) in oriens lacunosum moleculare (OLM) GABAergic interneurons ablate the facilitation of nicotine-induced hippocampal CA1 long-term potentiation and impair memory. The current study delineated whether genetic mutations of a2* nAChRs ("Chrna2"[superscript L9'S/L9'S] and…
Descriptors: Brain, Brain Hemisphere Functions, Animals, Long Term Memory
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Cole, Sydni M.; Reysen, Matthew B.; Kelley, Matthew R. – Journal of Experimental Psychology: Learning, Memory, and Cognition, 2013
Part-set cuing "inhibition" refers to the counterintuitive finding that hints--specifically, part of the set of to-be-remembered information--often impair memory performance in free recall tasks. Although inhibition is the most commonly reported result, part-set cuing "facilitation" has been shown with serial order tasks. The…
Descriptors: Cues, Spatial Ability, Task Analysis, Memory
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Rozas, Natalia S.; Redell, John B.; Pita-Almenar, Juan D.; McKenna, James, III.; Moore, Anthony N.; Gambello, Michael J.; Dash, Pramod K. – Learning & Memory, 2015
The mechanistic Target of Rapamycin Complex 1 (mTORC1), a key regulator of protein synthesis and cellular growth, is also required for long-term memory formation. Stimulation of mTORC1 signaling is known to be dependent on the availability of energy and growth factors, as well as the presence of amino acids. In vitro studies using serum- and amino…
Descriptors: Long Term Memory, Brain, Biochemistry, Cytology
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