Amphibians, a class of vertebrates consisting of frogs and toads, salamanders, and caecilians, are excellent organisms for middle school science students to study because of their ecological significance. Because they exchange oxygen and carbon dioxide through their skin, amphibians absorb any chemicals or substances present in their immediate environments. Malformations in or the absence of amphibians may suggest a problem in a given ecosystem. In this article, the author describes how amphibian malformations can be incorporated into inquiry-based lessons. The author also presents how these lessons can be introduced to students. (Contains 6 figures and 9 online resources.)