ERIC Number: EJ1120153
Record Type: Journal
Publication Date: 2016-Dec
Abstractor: As Provided
Brief Report: Autism Symptoms in Infants with Fragile X Syndrome
Roberts, Jane E.; Tonnsen, Bridgette L.; McCary, Lindsay M.; Caravella, Kelly E.; Shinkareva, Svetlana V.
Journal of Autism and Developmental Disorders, v46 n12 p3830-3837 Dec 2016
Fragile X syndrome (FXS) is the most common known genetic cause of autism spectrum disorder (ASD). Although 50-75% of children with FXS meet ASD criteria, no studies have compared ASD symptoms in infants with FXS versus other high risk groups, such as siblings of children with ASD (ASIBs). Using the Autism Observation Scale for Infants, our findings indicate that 53% of 12-month infants with FXS fall in the "at risk" category compared to 17 and 6% for age-matched ASIBs and controls, respectively. Elevated atypical motor behaviors were associated with elevated risk for FXS. Cross-syndrome comparisons are essential to understanding the heterogeneity of ASD and identifying candidate markers that will facilitate differential diagnosis of ASD in genetic disorders such as FXS.
Descriptors: Genetic Disorders, Intellectual Disability, Congenital Impairments, Infants, Autism, Pervasive Developmental Disorders, Comparative Analysis, Genetics, Siblings, Measures (Individuals), Observation
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A