Science provides a rich context for English learners (ELs) to develop language skills in meaningful ways. This article outlines steps to create a lesson that blends both inquiry science and formal English language development (ELD) strategies. The process, developed through a four-year research project in a large urban school district (Gomez-Zwiep et al. 2011), begins with a modified version of the 5E learning sequence (Bybee 1997), which the authors describe first. It is followed by a description within the 5E where EL instruction can be easily integrated.