ERIC Number: EJ1056667
Record Type: Journal
Publication Date: 2015-Apr
Abstractor: As Provided
The Class I HDAC Inhibitor RGFP963 Enhances Consolidation of Cued Fear Extinction
Bowers, Mallory E.; Xia, Bing; Carreiro, Samantha; Ressler, Kerry J.
Learning & Memory, v22 n4 p225-231 Apr 2015
Evidence indicates that broad, nonspecific histone deacetylase (HDAC) inhibition enhances learning and memory, however, the contribution of the various HDACs to specific forms of learning is incompletely understood. Here, we show that the Class I HDAC inhibitor, RGFP963, enhances consolidation of cued fear extinction. However, RGFP966, a strong inhibitor of HDAC3, does not significantly enhance consolidation of cued fear extinction. These data extend previous evidence that demonstrate the Class I HDACs play a role in the consolidation of long-term memory, suggesting that HDAC1 and/or HDAC2, but less likely HDAC3, may function as negative regulators of extinction retention. The development of specific HDAC inhibitors, such as RGFP963, will further illuminate the role of specific HDACs in various types of learning and memory. Moreover, HDAC inhibitors that enhance cued fear extinction may show translational promise for the treatment of fear-related disorders, including post-traumatic stress disorder (PTSD).
Descriptors: Inhibition, Memory, Cues, Cognitive Processes, Fear, Posttraumatic Stress Disorder, Long Term Memory, Biochemistry
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A