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ERIC Number: EJ820775
Record Type: Journal
Publication Date: 2007-Sep
Pages: 3
Abstractor: As Provided
Reference Count: 20
ISBN: N/A
ISSN: ISSN-0021-9584
A Knoevenagel Initiated Annulation Reaction Using Room Temperature or Microwave Conditions
Cook, A. Gilbert
Journal of Chemical Education, v84 n9 p1477-1479 Sep 2007
An experiment is presented that has the student execute a Knoevenagel initiated annulation reaction. The reaction can be carried out either through use of a microwave reactor or by allowing the mixture to stand at room temperature for two days. The student is then challenged to identify the reaction product through a guided prelab exercise of the synthesis of the Hagemann ester, and then through GC-MS, NMR, and IR spectra of the product. The stereochemistry of the product is determined through the NMR spectrum and the Karplus curve. The student is required to write a mechanism for the reaction. (Contains 2 figures.)
Division of Chemical Education of the American Chemical Society. Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Tel: 800-691-9846; Tel: 856-931-5825; Fax: 856-931-4115; e-mail: jchemed@egpp.com; Web site: http://www.jce.divched.org
Publication Type: Journal Articles; Reports - Evaluative
Education Level: Higher Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A