ERIC Number: EJ1041077
Record Type: Journal
Publication Date: 2014-Oct
Abstractor: As Provided
Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep
Goldman, Suzanne E.; Adkins, Karen W.; Calcutt, M. Wade; Carter, Melissa D.; Goodpaster, Robert L.; Wang, Lily; Shi, Yaping; Burgess, Helen J.; Hachey, David L.; Malow, Beth A.
Journal of Autism and Developmental Disorders, v44 n10 p2525-2535 Oct 2014
Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (C[subscript max]) and time to peak concentration (T[subscript max]) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin.
Descriptors: Sleep, Drug Therapy, Autism, Pervasive Developmental Disorders, Children, Outcomes of Treatment, Light, Metabolism
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A