The purpose of this article is to provide special education and general education teachers a framework (DIS[subscript 2]ECT) for teaching science in inclusive settings. DIS2ECT stands for Design (Backwards); Individualization; Scaffolding and Strategies; Experiential learning; Cooperative Learning; and Teamwork. This framework was derived from our experiences as special education and general education co-teachers, and was developed from a synthesis of evidence-based best practices in special education and science. (Contains 1 figure.)