This study examined the attitudes toward physical activity and exercise of university students enrolled in Personal Wellness classes. 1,625 undergraduate students completed the Attitudes Toward Exercise and Physical Activity (ATEPA) inventory on the first and last day of the class. Paired-samples t test results comparing the mean pretest ATEPA score to the mean posttest score revealed a significant improvement, ([bar.t](1624) = 2.91, [bar.p] is less than .01). A repeated measures multivariate analysis of variance (MANOVA) also revealed significant between-subjects effects for gender, [bar.F](1, 1579) = 30.23, [bar.p] is less than .01, and exercise history, [bar.F](2, 1579) = 35.16, [bar.p] is less than .01. Results suggest that students showed a significant improvement in attitude toward physical activity and exercise following completion of the university-required personal wellness course. Both exercise history and gender appeared to have influenced these effects.