Responding to challenges questioning the possibility of distinctively Catholic higher education, this article seeks to establish an integrated vision for Catholic universities. Relying on the works of Philip Gleason, Ignatius of Loyola, and Bernard Lonergan, the author provides a framework for the important research function of Catholic universities and conceives the mission of Catholic institutions of higher education as contributing to the ongoing, creative, and redemptive work that is ultimately God's plan for humanity.