This study aimed to learn more about the results of the research on the chemical literacy ability of junior high school students in South Sulawesi based on atomic, ionic and molecular materials. The samples in this study were Public Middle School 6 Makassar, Public Middle School 2 Maros and Public Middle School 4 Sinjai. Samples were taken randomly and as many as 181 students. The data were collected by using instruments consisting of multiple-choice tests that were used to collect data on knowledge and literacy competencies in chemical science. Aspects of knowledge discussed consisted of three indicators, and four indicators in aspects of literacy. The data that has been obtained were analyzed quantitatively. The results of research showed that there were differences between indicators of literacy skills, school level and interactions between students' chemical literacy competencies. The teacher must try to practice the students' scientific literacy skills. One effort that can be taken is the use of the appropriate learning models.