Screen media has become an intrinsic feature in the daily lives of children and youths with and without autism spectrum disorder (ASD). This systematic review provides a current overview concerning the significance of screen media in the lives of children and youths with ASD. For the years 2005 to 2016, we identified 47 studies covering media use among children and youths with ASD. These studies concordantly showed screen media as being a preferred leisure activity for children and youths with ASD, and reported mixed evidence compared to children without ASD. Further research on content, functionality, problematic media use, other leisure time activities, and quality of life is recommended.