Universal design for learning (UDL) holds promise for teachers who are struggling with creating lessons that allow all students access to and engagement with the general science curriculum. In this article, the authors demonstrate how a secondary physical science lesson about solubility and concentration can be designed for diverse learners' needs by implementing UDL concepts. The lesson plan serves as an example of UDL in providing appropriate instruction that supports access to the general physical science curriculum for all learners. (Contains 8 tables and 2 figures.)