A university level course which uses minicomputers in laboratory data acquisition and experimental control is described. The majority of the students are chemistry seniors and graduate students; prerequisites are general physics and one semester of computer science or programing experience. The goals of the course, which is divided into 3 5-week parts, are to develop a systematic technique for data acquisition and control of an analytical instrument using a digital computer. The first part of the course deals with the electronics involved in interfacing; the second part concentrates on programing the computer to do an analysis of the data and the assembler language subroutines; the third part is devoted to individual student projects. The majority of the programing is done in BASIC which was chosen for its ease in learning, its immediate debugging capabilities and its comparability with previous teaching experience. A list of projects performed by students at Texas Christian University during the past two years is included, as is a course schedule. (Author/KKC)