This study aimed to examine the effect of alienation from the academic profession (AAP) on organizational deviance (OD) and the mediating role of job satisfaction (JS) in this relationship. A quantitative correlational design was employed. Structural equation modeling was used to analyze the data gathered from 257 academics in Turkey. The results show that AAP, directly and indirectly, affected OD. This research indicates that AAP is important in OD. Results also highlighted the direct effect of alienation from academic profession on JS and JS on OD. In addition, JS had a mediator effect between AAP and OD. Consequently, to prevent academics from displaying deviant behaviors, it is important to increase their JS by avoiding the perception of alienation.