Normal phase thin layer chromatography is a widely taught technique in undergraduate organic chemistry laboratory courses. To understand how the technique works, students must have a strong conceptual understanding of polarity and intermolecular forces. Unfortunately, many students have misconceptions regarding how polarity and intermolecular…

Tofu, a traditional Chinese food, is now popular worldwide. However, few people notice the chemistry that is involved in its production. To shed light on this, we have designed a simple demonstration for lower-level undergraduates in organic chemistry or biochemistry courses to help them understand the chemistry principles that underlie the…

Appealing to students' affect in academic settings, such as demonstrating chemistry's relevance to their life, is one strategy instructors may use to support students' in learning. This study investigates the types of connections that students make to organic chemistry when responding to an open-ended writing assignment. Students enrolled in an…

A multicomponent reaction was adapted and successfully applied in the major organic course, which involves synthesizing and characterizing a 1,3-benzoxazine derived from paracetamol extracted from tablets of the worldwide well-known medicine Tylenol. Using paracetamol as a reagent is a motivational strategy in undergraduate laboratories to meet…

Despite representations' central role in conveying chemical phenomena, mastering them is not trivial, given the wide variety of different conventions to interpret and use them. Furthermore, instructional approaches and materials may overlook explicit discussion on how students should reason with representations. To gather evidence that could guide…

Despite the important role organic chemistry plays in a wide range of industries, the undergraduate organic chemistry course sequence is considered to be difficult for and feared by students. Although work has been done to identify and address student difficulties within the cognitive and psychomotor domains, little work has focused on…

Organic chemistry is accepted as a crucial part of science higher education funneling students into many career opportunities such as pharmaceuticals, biotechnology, and medical industries. Students attempting organic chemistry courses in higher education are among a plethora of majors including biology, chemistry, health science, and engineering.…

High-resolution mass spectrometry (HRMS) is an analytical technique that is typically used by mass spectrometry experts. However, with recent advancements, it is becoming more accessible to students in organic chemistry laboratories. Still, a significant knowledge gap exists between these experts and students. A straightforward laboratory…

The imine condensation reaction is commonly addressed in second semester organic chemistry classrooms as imines and their derivatives are found in many pharmaceutical scaffolds and biological and catalytic processes. Despite this, imine condensations are still absent from many organic chemistry laboratory curriculums. The work discussed here…

Practice examinations developed at the ACS Examinations Institute ask students to self-report mental effort when answering items. This self-reported mental effort together with performance can be represented in the form of a cognitive efficiency graph for each student giving information on the utilization of cognitive resources and content…

Applying the idea of green chemistry, we extended an esterification teaching experiment with isoamyl alcohol and acetic acid and reused isoamyl acetate in the transesterification reaction with KOH as the catalyst. As a result, isoamyl alcohol was produced and could be reused for the teaching experiment. The simplified experimental method achieved…

Resonance is a crucial concept in Organic Chemistry that enables both deriving chemical properties from molecular structures and predicting reactions by considering electron density distribution. Despite its importance for problem-solving and learning success, learners encounter various difficulties with this concept. Although prior research…

A comprehensive teaching experiment plan tailored forthird-yearundergraduates has been developed. Initially, instructors synthesize(E)-2-(4-((4-(2-hydroxyethoxy)-3-methylphenyl)­diazenyl)­phenoxy)-ethan-1-ol­(M-Azo-2)monomer as part of the preclass preparation. Subsequently, studentsperform an acylation reaction experiment to prepare an…

The Brønsted-Lowry acid-base model is fundamental when discussing acid and base strength in organic chemistry as many of the reactions include a competing proton transfer reaction. This model requires evaluating chemical stability "via" a consideration of electronic granularity. The purpose of this study is to identify students' mental…

Electrophilic aromatic substitution reactions are common in the organic chemistry laboratory. These reactions, while ubiquitous, use corrosive reagents and halogenated or hydrophobic solvents that produce expensive and hazardous waste streams. The carboxylation of phenols (Kolbe-Schmitt reaction), although aqueous, typically involves conditions…