The rising costs of college tuition, housing, and textbooks can be a barrier to many who seek a certification or degree in a health profession field. Affordable open educational resources (AOER) are an attractive alternative to expensive course materials. The Health Sciences Department at Weber State University created a comprehensive, two semester anatomy and physiology course using only openly available, copyright-free educational resources and an inexpensive, interactive laboratory program. The product is a collection of resources that includes a 1000+ page study guide, more than 230 small formative learning activities, recorded video lectures, and a comprehensive laboratory program that functions in both online and campus-based environments. This paper outlines the steps taken to transition from a traditional textbook-centered anatomy and physiology curriculum to one that offers students a wide range of learning resources for a fraction of the cost. The reduction of course materials costs will save health sciences students at Weber State University more than $375,000 every year.