Objectives: The current study aimed at examining the effectiveness of group logotherapy to enhance psychological well-being of mothers of children with intellectual disabilities. Method: The methodology adopted in this study was quasi-experimental incorporating pre-test, post-test, and control group. The population comprised all mothers of children with intellectual disabilities in Bushehr City, Iran. To this end, 26 mothers of children with intellectual disabilities were chosen using multi-stage sampling and were randomly divided into two groups of 13 as experimental and control groups. To gather data, Ryff's psychological well-being inventory was employed, and then the experimental group was treated by eight sessions of logotherapy group counseling each of which lasted 90 min. There was no intervention for the control group and both groups were post-tested. Results: Analyzed by statistical covariance, the results demonstrated that group logotherapy leads to increased psychological well-being and its subscales including positive relationships with others, autonomy, personal growth, and environmental mastery. Conclusion: According to the findings, it is concluded that group instruction with logotherapy approach influences the psychological well-being of mothers of children with intellectual disabilities and one can use this style to help improve parents' mental health.