Moral Disengagement (MD) has been found to be related to higher levels of different aggressive and bullying behaviours. Although some studies found that it plays an important role in cyberbullying too, results in this field are still puzzling and the association between MD and cyberbullying is still unclear. Therefore, this systematic review was aimed at examining evidence of the association between MD and cyberbullying. We analysed 41 studies, seeking to clarify how cyberbullying perpetrating, and active and passive bystanding behaviours are associated with MD mechanisms, and how the association among these processes may vary depending on the methods of measurement chosen. Taken together, the results confirm that positive associations among MD and both cyberbullying perpetrating and passive bystanding behaviours are significant, even after the roles of moderating variables are accounted for. Results are discussed in terms of their implications for future research and intervention.