In this paper, we investigate the choice of English as a home language in Ghana, a multilingual nation where 81 languages are spoken by a population of about 27 million people. In the past, while English was reserved as the de facto language of official domains, e.g., government business and education, Ghanaian languages were used in informal domains such as homes, markets and churches. Recent research and observations show a gradual shift from the use of indigenous languages in some informal domains to the use of the English language, especially in urban centres. This study uses audio-recordings, questionnaires and observations to gather data from 20 homes from 2 geographically and socio-economically distinct urban communities in Accra. The findings of the study show that economic status, age, inter-ethnic marriages and educational background are the main factors influencing the choice of English as a home language in urban Ghana. Other factors, such as the media, the language in education policies and the use of the internet, also play a role in the use of English in Ghanaian homes.