A study to present specific hypothesis that satisfactorily explain the boiling point of a number of molecules, CH[subscript w]F[subscript x]Cl[subscript y]Br[subscript z] having similar structure, and then analyze the model with the help of multiple linear regression (MLR), a data analysis tool. The MLR analysis was useful in selecting the predictor variables that could significantly clarify the boiling point variation of CH[subscript w]F[subscript x]Cl[subscript y]Br[subscript z] molecules.