This study investigates the extent to which female teachers in Ghana are able to balance their careers and social roles, while acting as role models in career progression. Work-life balance (WLB) is a phenomenon gaining much interest in educational administration and management in Ghana. The Ghana Education Service (GES) employs a significant number of female teachers, yet evidence shows practical policy issues when it comes to WLB. Study respondents indicated their perceptions of significant sociocultural challenges in trying to balance domestic roles and teaching. Some support systems were identified, but they were not found to have a significant effect on female teachers' resilience and determination to consolidate their career in GES. The results have several implications for GES policy direction, practices for performance, and recommendations for scaling up WLB research in Ghana.