Previous research suggests that identifying as a first-generation college student means more experiences of single-event traumatic stress, lower levels of life satisfaction, higher levels of depressive symptoms, and higher levels of achievement guilt (Jenkins et al., 2013; Covarrubias et al., 2015). To date, little research has examined the role that family support plays in first-generation college student mental health. The purpose of this quantitative study (N = 113, 59 first-generation, 58 continuing-generation college students) was to examine the extent to which family support and/or family over-involvement may differentially contribute to the mental health and well-being of first-generation and continuing-generation college students. Results from the survey showed that students across generational groups who reported lower levels of family support also reported more severe depression symptoms and lower levels of well-being. It was also found that continuing-generation students reported higher levels of well-being and higher levels of family cohesion compared to first-generation students. This study's findings should be interpreted in light of its limitations, including its sample size, demographic homogeneity of participants, relatively low levels of clinically significant mood and anxiety symptoms among the participants, and potentially limited generalizability as data was collected during the COVID-19 pandemic. Future research may consider the role of potential clinician bias, such that due to a cultural mismatch between the college and student's culture the clinician makes assumptions about the culture of the first-generation student, and what it would look like to include family work in counseling centers. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]