This manuscript introduces a multidimensional framework for academic literacies to help instructors become more aware of different aspects of literacies and how they might be used to plan and orchestrate meaningful, multifaceted literacy experiences in their classes. More specifically, this broad framework for literacy and learning explicitly considers the overlapping role of argumentation, digital inquiry, collaboration, and innovation as they are applied to continuously evolving disciplinary literacy practices. The framework is applied to a course designed for pre-service teachers that integrated several aspects of academic literacies and offered some pedagogical guidelines to support their literacy development. A summary of the different domains of academic literacies and research-based pedagogical guidelines is provided to assist teachers in various disciplines and educational levels in applying the framework in their own instructional contexts.