Comments on the article by J. S. Hyde (see record 2005-11115-001), in which Hyde reviewed meta-analytic evidence on gender differences and concluded that most psychological gender differences are in the close-to-zero or small range. The current author notes some omissions from Hyde's review, including the findings through other research large gender differences are reflected in some kinds of interests and occupational preferences, in males' and females placement on the people-things dimension of interests, and in many kinds of mental illness and behavior problems. The current author's position is that that many psychological gender differences are small-to-nonexistent, some are moderate, and some are large. The task that confronts gender researchers is to explain the complex profile of psychological gender differences and to untangle the myriad social and biological factors that generate both gender differences and gender similarities.