"Ready, Set, Leap!"[R] is a preschool curriculum that focuses on early reading skills, such as phonemic awareness, letter knowledge, and letter-sound correspondence, using multisensory technology that incorporates touch, sight, and sound. Teachers may adopt either a theme-based or a literature-based teaching approach, and for each approach, the curriculum provides lesson plans, learning objectives, and assessment tools. The What Works Clearinghouse (WWC) reviewed three studies on "Ready, Set, Leap!"[R]: two of these studies meet WWC evidence standards and the other did not meet WWC evidence standards. Based on the two studies, the WWC found no discernible effects for oral language, print knowledge, phonological processing, early reading/writing, and math. The conclusions presented in this report may change as new research emerges. Six appendixes are included: (1) Study Characteristics: RMC Research Corporation; (2) Study Characteristics: PCER Research Corporation; (3) Summary of Study Findings; (4) Summary of Kindergarten Follow-Up Findings; (5) "Ready, Set, Leap!"[R] Ratings; and (6) Extent of Evidence by Domain. (Contains 80 footnotes.)