According to the "Diagnostic and Statistical Manual of Mental Disorders" (DSM-IV-TR; American Psychiatric Association, APA, 2000), autism is a neurodevelopmental disorder that is characterized by impairments in social and communicative behaviors with great variations in ability, depending on developmental level, intelligence, and chronological age. One common thread for all individuals who are diagnosed with autism is that if interventions are not designed to meet the individual's needs in a socially significant manner, the individual has a poor prognosis (Heward, 2009). Two of the more common tools for teaching communication skills to individuals with disabilities related to communication are the Picture Exchange Communication System (PECS; Bondy & Frost, 1994), which relies on the exchange of pictures representing a desired object, place, or event, and mand training (Rosales & Rehfeldt, 2007; Skinner, 1957). The term "mand" is defined as "a verbal operant for which the form of the response is under the functional control of motivating operations and specific reinforcement" (Cooper, Heron, & Heward, 2007, p. 30); that is, people request specific items or things only when they are motivated to do so. The primary goal of this study was to teach a nonverbal man who was blind and was diagnosed with autism to use sign language to mand for two highly desirable items: food and drink. (Contains 4 figures.)