In December 2019, Coronavirus disease (COVID-19) emerged in Wuhan, China that culminated in a serious pandemic condition. Physical distancing restrictions were a significant component of the public health emergency response to the COVID-19 pandemic. For children and youth, these restrictions included safety measures that impacted daily activities related to physical activity (PA) participation worldwide. Preliminary evidence suggests that in children with special needs such as Autism Spectrum Disorder (ASD), COVID-19 restrictions may have disproportionally led to reduced levels of PA. The aim of this study was to review the benefits of PA for children with ASD and suggest Home PA Program examples for Children with ASD during COVID-19 pandemic and the quarantine time.