This study examined whether a relationship exists between acculturation and alcohol use among African American college students and if the relationship varies by religiosity and gender. Most researchers use unidimensional African American acculturation measures that cannot capture the construct's complexity; this study is the first to use a bidimensional measure. Results revealed a relationship between acculturation and alcohol use. Less frequent drinking occurred among marginalists (those who reject both African and Eurocentric U.S. culture), while assimilationists (those who reject African culture in favor of Eurocentric U.S. culture) drank more frequently. Religiosity and gender also significantly influenced the nature of the relationship. (Contains 3 tables and 2 figures.)